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Compliant_bronchiole_compliant_alveolus

This model represents a compliant bronchiole with a compliant alveolar sac. The driving force for this model is a pressure gradient which represents the difference in the alveolar and the pleural pressures.

Model number: 0125

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Description

 This model represents a compliant bronchiole with a compliant alveolar sac.
 The resistance offered by bronchial wall to the flow of air is represented by 
 the resistor in the model. The total resistance of the bronchiole is split into 
 two resistors in series to fecilitate smooth coupling of downstream circuits. 
 The compliance of the bronchiole is represented by the capacitor. The alveolar sac
 compliance is repsented by a capcitor. The alveolar sac changes its volume as a 
 function of inlet flow or pressure. The driving force for this model is the pressure 
 gradient which represents the pressure difference between the alveolar sac and the 
 pleural pressure. Since this model lacks a pleural cavity, a positive pressure
 gradient is imposed to drive the flow into the alveolar sac. The important difference 
 between this model and the rigid_bronchiole_compliant_alveolus model is the shape of 
 alveolar volume curve. 


Legend:
Finlet: Inlet Flow, P: Pressure, R: Resistance, F: Flow, Com: Compliance, V: Volume.

Equations

Pinlet - P2 = Finlet * R1
F1 = Finlet - F2
P2 = (V1 - V1_0)/Com1
P2 - P3 = F1 * R2
P3 - P4 = F1 * R3
P4 = (V2 - V2_0)/Com2
d(V1)/dt = F2   
d(V2)/dt = F1

Where: P is pressure, F is flow, R is resistance, Com is capacitance, and V is the volume. 

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References

      K. R. Lutchen and G. M. Saidel, "Estimation of mechanical parameters in multicompartment 
      models applied to normal and obstructed lungs during tidal breathing," 
      IEEE Trans. Biomed. Eng., vol. BME-33, no. 9, pp. 878-887, Sept. 1986.

      Fung Y.C.; Biomechanics (Text Book)

Related Models

Key Terms

Compliant Bronchiole, Bronchiolus, Alveolus, Alveolar sac, Respiratory system, respiratory mechanics, airway

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Acknowledgements

Please cite www.physiome.org in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 02Nov16, 2:27 pm.]

Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.